Please use this identifier to cite or link to this item:
http://repositorio.ugto.mx/handle/20.500.12059/373
Full metadata record
DC Field | Value | Language |
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dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0 | es_MX |
dc.contributor.author | Lissett Esther Martínez Magaña | - |
dc.contributor.author | CLARA ALBA BETANCOURT | - |
dc.creator | RAFAEL RODRIGUEZ CORTES | es_MX |
dc.date | 2017-01 | - |
dc.date.accessioned | 2018-08-14T06:25:36Z | - |
dc.date.available | 2018-08-14T06:25:36Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.uri | http://www.repositorio.ugto.mx/handle/20.500.12059/373 | - |
dc.description.abstract | Evaluar la utilidad de la HbA1c como predictor de la disfunción de las células B pancreáticas y la resistencia a insulina en pacientes sin diagnóstico previo de diabetes. Estudio de prueba diagnóstica en 455 sujetos voluntarios de 18 - 65 años sin diagnóstico previo de diabetes tipo 2 (DT2). | es_MX |
dc.language.iso | spa | es_MX |
dc.relation | http://repositorio.ugto.mx/handle/20.500.12059/373 | - |
dc.rights | info:eu-repo/semantics/openAccess | es_MX |
dc.subject.classification | CLE- Maestría en Investigación Clínica | es_MX |
dc.title | Utilidad de la hemoglobina glucosilada A1c para predecir disfunción de células beta pancreáticas y resistencia a insulina en población mexicana sin diagnóstico previo de diabetes | es_MX |
dc.type | info:eu-repo/semantics/masterThesis | es_MX |
dc.creator.id | info:eu-repo/dai/mx/curp/ROCR861210HTCDRF05 | es_MX |
dc.subject.cti | info:eu-repo/classification/cti/32 | es_MX |
dc.subject.keywords | Ciencias Médicas | es_MX |
dc.subject.keywords | Ciencias clínicas | es_MX |
dc.contributor.role | analista | es_MX |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_MX |
dc.contributor.one | María de Lourdes Reyes Escogido | es_MX |
dc.contributor.two | RODOLFO GUARDADO MENDOZA | es_MX |
dc.contributor.idone | info:eu-repo/dai/mx/curp/REEL730214MZSYSR07 | es_MX |
dc.contributor.idone | info:eu-repo/dai/mx/cvu/161750 | - |
dc.contributor.idtwo | info:eu-repo/dai/mx/curp/GUMR740407HJCRND04 | es_MX |
dc.contributor.roleone | director | es_MX |
dc.contributor.roletwo | director | es_MX |
dc.contributor.rolethree | analista | es_MX |
dc.contributor.rolefour | analista | es_MX |
dc.contributor.rolefive | analista | es_MX |
dc.contributor.rolesix | analista | es_MX |
dc.publisher.university | Universidad de Guanajuato | es_MX |
dc.description.abstractEnglish | To assess the usefulness of HbA1c as a predictor of pancreatic B-cell dysfunction and insulin resistance in patients without prior diagnosis of diabetes. Diagnostic test study in 455 volunteer subjects aged 18-65 years without previous diagnosis of type 2 diabetes (DT2). | es_MX |
dc.description.abstractEnglish | Introduction: Several studies have related acute pancreatitis processes with obesity and high triglycerides levels. Objective: To assess the effect of metformin on the alterations in triglycerides and amylase serum levels caused by a high fructose, fat and cholesterol diet (HFFCD). Materials and methods: For 7 weeks, male New Zealand rabbits were subjected to HFFCD. The body weight variation was measured as well as amylase and triglycerides serum levels at the end of HFFCD. Three rabbits were treated with metformin (300mg/kg/día). Results: The HFFCD group showed a gain of 8.5 +/- 2.6 % in the body weight, as well as an increase of 20.6 +/- 6.7% and 29.6 +/- 4.7 % in the serum levels of amylase and triglycerides, respectively, compared to control. The two HFFCD rabbits were dead after two doses of metformin. Discussion-conclusion: The triglycerides levels observed in the HFFCD group, suggest an alteration in the pancreatic activity due to the establishment of an acute pancreatitis, which leads to an increase in amylase levels, facilitating the conditions that contribute to the development of other diseases related to obesity. We suspect a HFFCD and metformin associated acidosis as the cause of death. | - |
Appears in Collections: | Maestría en Investigación Clínica |
Files in This Item:
File | Description | Size | Format | |
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157203.pdf | 3.8 MB | Adobe PDF | View/Open |
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