1. Repositorio Institucional de la Universidad de Guanajuato
  2. Tesis
  3. Tesis de Posgrado
  4. CGU - Campus Guanajuato. Tesis de Posgrado
  5. DCNE - División de Ciencias Naturales y Exactas. Tesis de Posgrado
  6. Doctorado en Química
Please use this identifier to cite or link to this item: http://repositorio.ugto.mx/handle/20.500.12059/8129
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dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.contributorCESAR ROGELIO SOLORIO ALVARADOes_MX
dc.creatorNarendra Malien
dc.date.accessioned2023-04-26T18:06:49Z-
dc.date.available2023-04-26T18:06:49Z-
dc.date.issued2022-
dc.identifier.urihttp://repositorio.ugto.mx/handle/20.500.12059/8129es_MX
dc.language.isoengen
dc.publisherUniversidad de Guanajuatoes_MX
dc.rightsinfo:eu-repo/semantics/openAccesses_MX
dc.subject.classificationCGU- Doctorado en Ciencias Químicas (Tradicional)es_MX
dc.title1) Iodine(III)-mediated the electrophilic iodination of free-anilines using the PIDA/NH4I system. and 2) Gold(I)-catalyzed intermolecular alkyne dimerization for the synthesis of pentacyclic bisindolic trans-fused system via domino processes_MX
dc.typeinfo:eu-repo/semantics/doctoralThesises_MX
dc.creator.idinfo:eu-repo/dai/mx/orcid/0000-0003-4976-7600es_MX
dc.subject.ctiinfo:eu-repo/classification/cti/7es_MX
dc.subject.ctiinfo:eu-repo/classification/cti/33es_MX
dc.subject.ctiinfo:eu-repo/classification/cti/3303es_MX
dc.subject.keywordsIodine (III)en
dc.subject.keywordsElectrophilic iodination of free-anilinesen
dc.subject.keywordsPIDA/NH4I system [(Diacetoxyiodo) benzene] and Ammonium iodide]en
dc.subject.keywordsIntermolecular alkyne dimerization - Gold(I)-catalyzeden
dc.subject.keywordsPentacyclic bisindolic trans-fused system – Synthesisen
dc.subject.keywordsDomino process (Chemistry)en
dc.contributor.idinfo:eu-repo/dai/mx/cvu/164887es_MX
dc.contributor.roledirectoren
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_MX
dc.description.abstractEnglishThis dissertation contains one general introduction and two experimental chapters, which are outlined below. 1. In chapter I dissuasion about the general introduction, there are two topics discussed based on the research carried out in the doctoral thesis. In the first part, the background of hypervalent iodine compounds, their synthesis methods, and applications in organic synthesis, and in the second part, gold(I) catalysis with wide use in organic transformation have been described. 2. In chapter II, we developed a gold(I)-catalyzed intermolecular alkyne dimerization for the Synthesis of pentacyclic bisindolic trans-fused system via domino process The scope of the protocol was determined by synthesizing some electron-neutral, electron-poor as well as electron-rich derivatives. Also, we studied X-Ray Crystallography, The mechanism of this reaction is following an intermolecular pathway by 5-endo-dig cyclization to pentacyclic bisindolic trans-fused dimer. 3. In chapter III, The first iodine(III)-mediated para-selective iodination protocol for free-anilines as well as the mechanistic elucidation of the reaction pathway is described. The developed method proceeded under clean, non-toxic, efficient and in general mild reaction conditions. To the best of our knowledge this report describes for the first time a procedure focused specifically on the introduction of an iodine atom in free anilines using PIDA [(diacetoxyiodo)benzene] and ammonium iodide which formed in situ acetyl hypoiodite (AcO-I) as the halogenating species. Our DFT calculations suggest a reaction mechanism that highlights the role of the ammonium cation in the AcO-I formation and halogenation. Considering there are few procedures for the iodine atom introduction in anilines using non-acidic conditions, herein we described an initial report on a mild and operationally simple alternative using iodine (III) reagents / Narendra Sukalal Mali ; Director: César Rogelio Solorio Alvarado.en
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