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http://repositorio.ugto.mx/handle/20.500.12059/920
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DC Field | Value | Language |
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dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0 | es_MX |
dc.creator | MARIA DEL CARMEN GARCIA RODRIGUEZ | es_MX |
dc.date | 2017-08-02 | - |
dc.date.accessioned | 2019-06-20T19:06:33Z | - |
dc.date.available | 2019-06-20T19:06:33Z | - |
dc.date.issued | 2017-08-02 | - |
dc.identifier.uri | http://repositorio.ugto.mx/handle/20.500.12059/920 | - |
dc.description.abstract | Se evaluó la cito/genotoxicidad en sangre periférica de ratones CD-1 expuestos a las variedades de vino tinto Cabernet Sauvignon, Merlot, Carménère y Cabernet Sauvignon/Nebbiolo. Grupos de cinco organismos fueron tratados: a) con el vehículo, b) vino tinto o etanol (diluidos al 75% y 10%, respectivamente) ad libitum, y c) vino tinto sin diluir o etanol diluido al 13.5% (dos dosis diarias-0.25 ml, intragástricamente [i.g.]). La cito/genotoxicidad se evaluó mediante el ensayo de micronúcleos (MN) y la relación entre eritrocitos policromáticos/normocromáticos (EPC/ENC) a las 0 h, 24 h, 48 h y 72 h. La administración i.g. de Cabernet Sauvignon, Merlot y etanol mostraron ligeros incrementos en los MN que resultaron significativos; sin embargo, la administración ad libitum de los vinos mostró una tendencia a reducirlos. Nuestros hallazgos sugieren que los MN podrían estar relacionados con la biodisponibilidad, farmacodinámica y farmacocinética del etanol y de los antioxidantes del vino tinto. No se observaron efectos citotóxicos. | es_MX |
dc.format | application/pdf | - |
dc.language.iso | spa | es_MX |
dc.publisher | Universidad de Guanajuato | es_MX |
dc.relation | http://actauniversitaria.ugto.mx/index.php/acta/article/view/1221 | - |
dc.rights | info:eu-repo/semantics/openAccess | es_MX |
dc.source | Acta Universitaria. Multidisciplinary Scientific Journal. Vol 27 No 3 (2017) | - |
dc.source | ISSN: 2007-9621 | - |
dc.title | Efecto de la administración intragástrica y ad libitum del vino tinto (Cabernet Sauvignon, Merlot, Carménère y Cabernet Sauvignon/Nebbiolo) y del alcohol en la cito/genotoxicidad evaluada en sangre periférica de ratones CD-1 | es_MX |
dc.title.alternative | The effect of intragastric and ad libitum administration of red wines (Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo) and alcohol in the cyto/genotoxicity evaluated in the peripheral blood of CD-1 mice | en |
dc.type | info:eu-repo/semantics/article | es_MX |
dc.creator.id | info:eu-repo/dai/mx/cvu/25187 | es_MX |
dc.subject.cti | info:eu-repo/classification/cti/6 | es_MX |
dc.subject.keywords | Vino tinto | es_MX |
dc.subject.keywords | Genotoxicidad | es_MX |
dc.subject.keywords | Citotoxicidad | es_MX |
dc.subject.keywords | Alcohol | es_MX |
dc.subject.keywords | Red wine | en |
dc.subject.keywords | Genotoxicity | en |
dc.subject.keywords | Micronúcleos | es_MX |
dc.subject.keywords | Micronucleus | en |
dc.subject.keywords | Cytotoxicity | en |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_MX |
dc.creator.two | GABRIELA GUERRERO PALOMO | es_MX |
dc.creator.three | MARIO AGUSTIN ALTAMIRANO LOZANO | es_MX |
dc.creator.idtwo | info:eu-repo/dai/mx/cvu/371305 | - |
dc.creator.idthree | info:eu-repo/dai/mx/cvu/9364 | - |
dc.description.abstractEnglish | We evaluated the cyto/genotoxicity in peripheral blood of CD-1 mice exposed to different varieties of red wine Cabernet Sauvignon, Merlot, Carménère and Cabernet Sauvignon/Nebbiolo. Groups of five CD-1 mice were treated with: a) vehicle only; b) red wine or ethanol ad libitum (diluted 75% and 10%, respectively); c) undiluted red wine or ethanol diluted to 13.5% (two daily doses-0.25 ml via intragastric [i.g.]). The cyto/genotoxicity was evaluated by micronucleus (MN) assay, and by the relationship between polychromatic/monochromatic erythrocytes at 0 h, 24 h, 48 h and 72 h. Significant but slight increases of MN were observed only in the treatments i.g. of Cabernet Sauvignon, Merlot, and ethanol. However, the administration ad libitum of red wines tended to decrease the MN. Our findings suggest that the MN could be related with the bioavailability, pharmacodynamics, and pharmacokinetics of ethanol and the antioxidants of red wine. No cytotoxic effects were observed. | en |
Appears in Collections: | Revista Acta Universitaria |
Files in This Item:
File | Description | Size | Format | |
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1221-Article Text-25536-1-10-20170906.pdf | 619.18 kB | Adobe PDF | View/Open |
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