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http://repositorio.ugto.mx/handle/20.500.12059/5166
Title: | Organocatalytic cascade reaction for the synthesis of polycylic compounds utilizing Trienamine activation |
Authors: | SUHAS BALASAHEB MITKARI |
Authors' IDs: | info:eu-repo/dai/mx/cvu/787089 |
Abstract: | We report an Aminocatalytic privileged Diversity-Oriented Synthesis (ApDOS) strategy via trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring closing sequence by using dithioamides as activated heterodienophiles. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet-Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation, open new perspectives for the synthesis of a new class of complex and diverse thiopyrans, which contribute to populate new relevant regions in the chemical space. |
Issue Date: | 2021 |
Publisher: | Universidad de Guanajuato |
License: | http://creativecommons.org/licenses/by-nc-nd/4.0 |
URI: | http://repositorio.ugto.mx/handle/20.500.12059/5166 |
Language: | eng |
Appears in Collections: | Doctorado en Química |
Files in This Item:
File | Description | Size | Format | |
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SUHAS BALASAHEB MITKARI_Tesis24.pdf | 12.31 MB | Adobe PDF | View/Open |
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